Title

Effects of β-Funaltrexamine and Naloxonazine on Single-Trial Morphine-Conditioned Place Preference and Locomotor Activity

Document Type

Article

Publication Date

2-2003

Department

Psychology

Language

English

Publication Title

Pharmacology, Biochemistry, and Behavior

Abstract

The current study assessed the ability of the selective irreversible μ-opioid receptor antagonists β-funaltrexamine (βFNA) and naloxonazine (NALZ) to alter the locomotor and rewarding effects of a single intravenous injection of morphine using the conditioned place preference (CPP) model. In the first experiment, rats were conditioned with a single injection of morphine (10 mg/kg iv) paired with one compartment of a CPP apparatus and then were tested for CPP at either 1 or 7 days after conditioning. Rats showed hypoactivity following acute morphine on the conditioning trial and showed CPP when tested either 1 or 7 days later. In the next experiments, rats were pretreated with βFNA (20 mg/kg sc, 20 h before conditioning), NALZ (15 or 30 mg/kg sc, 24 h before conditioning) or saline and then were conditioned with a single injection of morphine (10 mg/kg iv) or saline. Pretreatment with NALZ alone, but not βFNA, significantly decreased locomotor activity; neither antagonist alone produced a significant shift in preference for either compartment of the CPP apparatus. Pretreatment with either βFNA or NALZ blocked completely morphine-induced hypoactivity, but neither antagonist had a significant effect on morphine CPP. These results indicate that μ-opioid receptors are more critically involved in acute morphine-induced hypoactivity than in acute morphine reward.

Comments

For more information on the published version, visit Science Direct's Website.

DOI

10.1016/S0091-3057(02)01049-3

Full text currently unavailable.

COinS