Title
Determination of the Regiochemistry of Disubstituted Arenes Generated by Addition of a Carbanion to the (η6-Anisole)Cr(CO)3 Complex
Roles
Samantha B. Charlton: Student co-author.
Document Type
Article
Publication Date
1-2001
Department
Chemistry
Language
English
Publication Title
Journal of Chemical Education
Abstract
It has become increasingly important to demonstrate to undergraduates that chemistry is not many separate subfields, but rather a set of interconnected concepts. We describe a laboratory activity that integrates fundamental concepts of organic and organometallic chemistry and then employs standard instrumental techniques (GC) and molecular modeling to justify the results. Students synthesize the (η6-anisole)Cr(CO)3 complex and react it with the -:CH2CN anion to generate methoxyphenylacetonitrile. They then determine the relative amounts of the three possible regioisomers of the disubstituted arene using GC. We have shown this synthesis to be straightforward for students to accomplish, with results that are reproducible.
DOI
10.1021/ed078p68
Recommended Citation
Bengali, Ashfaq A., Cindy Samet, and Samantha B. Charlton. "Determination of the Regiochemistry of Disubstituted Arenes Generated by Addition of a Carbanion to the (η6-Anisole)Cr(CO)3 Complex." Journal of Chemical Education 78, no. 1 (2001): 68-70.
Comments
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