Roles
Student author: Taylor Bednar
Student author: Alissa Resnikoff
Document Type
Article
Publication Date
4-29-2020
Department
Chemistry
Language
English
Publication Title
Amino Acids
Abstract
The cysteine- perfluoroarene SNAr reaction allows for the sequence-specific attachment of dyes and affinity tags to peptides and proteins. However, while many methods exist for the desulfuration of native and functionalized cysteine residues, there are no reports of their application to perfluoroarylated cysteines. Herein we report both the hydrogenolysis of a perfluoroarylated cysteine to alanine and elimination to dehydroalanine, reactions that are both accelerated by microwave irradiation.
DOI
10.1007/s00726-020-02846-z
Recommended Citation
Bednar, Taylor N.; Resnikoff, Alissa R.; and Gavenonis, Jason, "Microwave-Assisted Cleavage of Cysteine Perfluoroaryl Thioethers" (2020). Dickinson College Faculty Publications. Paper 1393.
https://scholar.dickinson.edu/faculty_publications/1393
Comments
Published as:
Bednar, Taylor N., Alissa R. Resnikoff, and Jason Gavenonis. "Microwave-Assisted Cleavage of Cysteine Perfluoroaryl Thioethers." Amino Acids (Article published online April 29, 2020). https://doi.org/10.1007/s00726-020-02846-z
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