Student author: Taylor Bednar
Student author: Alissa Resnikoff
The cysteine- perfluoroarene SNAr reaction allows for the sequence-specific attachment of dyes and affinity tags to peptides and proteins. However, while many methods exist for the desulfuration of native and functionalized cysteine residues, there are no reports of their application to perfluoroarylated cysteines. Herein we report both the hydrogenolysis of a perfluoroarylated cysteine to alanine and elimination to dehydroalanine, reactions that are both accelerated by microwave irradiation.
Bednar, Taylor N.; Resnikoff, Alissa R.; and Gavenonis, Jason, "Microwave-Assisted Cleavage of Cysteine Perfluoroaryl Thioethers" (2020). Dickinson College Faculty Publications. Paper 1393.