Voluntary Exercise Ameliorates Anxiogenic Effects of Acute Methamphetamine Exposure in Swiss-Webster Mice
The present experiment examined the ability of voluntary exercise (i.e., home-cage wheel running; HCWR) to ameliorate anxiety-like behavior associated with acute methamphetamine exposure in male, Swiss-Webster mice.
Mice were permitted access to home-cage running wheels (Exercise), locked home-cage running wheels or no home-cage running wheels (Sedentary) for 6 weeks and then exposed to different methamphetamine doses (vehicle, 0.25, 0.5, or 1.0 mg/kg) once weekly during an 8 h open-field session for 4 weeks. Group differences in hypothalamic-pituitary-adrenal (HPA) activity also were assessed by weighing adrenal glands.
It was found that HCWR ameliorated anxiety-like behavior after an injection of either the 0.5 or 1.0 mg/kg methamphetamine dose. Adrenal weights did not differ between Exercise and Sedentary mice.
Taken together, these results suggest that voluntary exercise ameliorates the anxiogenic effects of methamphetamine depending on the dose, perhaps via a non-HPA mechanism.
Rauhut, Anthony S. "Voluntary Exercise Ameliorates Anxiogenic Effects of Acute Methamphetamine Exposure in Swiss-Webster Mice." Pharmacological Reports 71 (2019): 1020-1024. https://doi.org/10.1016/j.pharep.2019.06.001