Roles

Student author: Leah M. Wachsmuth
Student author: Meredith G. Johnson

Document Type

Article

Publication Date

6-2017

Department

Chemistry

Language

English

Publication Title

PLOS Neglected Tropical Diseases

Abstract

Parasitic diseases caused by kinetoplastid parasites of the genera Trypanosoma and Leishmania are an urgent public health crisis in the developing world. These closely related species possess a number of multimeric enzymes in highly conserved pathways involved in vital functions, such as redox homeostasis and nucleotide synthesis. Computational alanine scanning of these protein-protein interfaces has revealed a host of potentially ligandable sites on several established and emerging anti-parasitic drug targets. Analysis of interfaces with multiple clustered hotspots has suggested several potentially inhibitable protein-protein interactions that may have been overlooked by previous large-scale analyses focusing solely on secondary structure. These protein-protein interactions provide a promising lead for the development of new peptide and macrocycle inhibitors of these enzymes.

Comments

This published version is made available on Dickinson Scholar with the permission of the publisher. For more information on the published version, visit PLOS's Website.

Open access publication of this article was made possible with grant support from Waidner-Spahr Library distributed through the Dickinson College Research & Development Committee.

DOI

10.1371/journal.pntd.0005720

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